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Lack of expected normal physiological development in childhood and adults. Real gains do not start showing until you have reached the third week. It soon caught popular attention and evolved into the concept we now call stacking- where two or more steroids are used at a time, to bring more gains and control side effects. This is not to say that you should avoid all primarily androgenic steroids. Anabolic Steroids in Sport and Exercise. Note that careless use of an aromatase inhibitor might lead to a drop in the level of HDL cholesterol the good cholesterol. They are in fact drugs that can seriously harm your body in many ways.

Anabolic Steroids

Since many athletes and power lifters also have to undergo steroid detection tests, they have to choose the steroids that they are going to use very carefully. This modification reduces the liver's ability to break down these compounds before they reach the systemic circulation. Steroid Cycles Introduction to Steroid Cycles Anabolic steroid cycles are used for one of three purposes. Both of these are SERM compounds. Other side-effects can include alterations in the structure of the heart , such as enlargement and thickening of the left ventricle , which impairs its contraction and relaxation , and therefore reducing ejected blood volume. Inexperienced anabolic steroid users will erroneously assume that the steroids are wholly responsible for their gains and so will increase their intake to get more results.

Although Ziegler prescribed only small doses to athletes, he soon discovered that those having abused Dianabol suffered from enlarged prostates and atrophied testes. Three major ideas governed modifications of testosterone into a multitude of AAS: The legal status of AAS varies from country to country: Unlawful distribution or possession with intent to distribute AAS as a first offense is punished by up to ten years in prison.

Those guilty of buying or selling AAS in Canada can be imprisoned for up to 18 months. In Canada, researchers have concluded that steroid use among student athletes is extremely widespread. A study conducted in by the Canadian Centre for Drug-Free Sport found that nearly 83, Canadians between the ages of 11 and 18 use steroids. AAS are readily available without a prescription in some countries such as Mexico and Thailand. The history of the U. The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of AAS and human growth hormone.

By the early s, after AAS were scheduled in the U. In the Controlled Substances Act, AAS are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens , progestins , and corticosteroids that promote muscle growth.

The act was amended by the Anabolic Steroid Control Act of , which added prohormones to the list of controlled substances , with effect from January 20, In the United Kingdom, AAS are classified as class C drugs for their illegal abuse potential, which puts them in the same class as benzodiazepines.

Part 1 drugs are subject to full import and export controls with possession being an offence without an appropriate prescription. There is no restriction on the possession when it is part of a medicinal product.

Part 2 drugs require a Home Office licence for importation and export unless the substance is in the form of a medicinal product and is for self-administration by a person. Many other countries have similar legislation prohibiting AAS in sports including Denmark, [] France, [] the Netherlands [] and Sweden.

United States federal law enforcement officials have expressed concern about AAS use by police officers. It's not that we set out to target cops, but when we're in the middle of an active investigation into steroids, there have been quite a few cases that have led back to police officers," says Lawrence Payne, a spokesman for the United States Drug Enforcement Administration.

Following the murder-suicide of Chris Benoit in , the Oversight and Government Reform Committee investigated steroid usage in the wrestling industry. The documents stated that 75 wrestlers—roughly 40 percent—had tested positive for drug use since , most commonly for steroids.

AAS are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad. As with most significant smuggling operations, organized crime is involved.

In the late s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents. In , Finnish authorities announced a record seizure of A year later, the DEA seized In the first three months of , Australian customs reported a record seizures of AAS shipments.

Illegal AAS are sometimes sold at gyms and competitions, and through the mail, but may also be obtained through pharmacists, veterinarians, and physicians. AAS, alone and in combination with progestogens , have been studied as potential male hormonal contraceptives. From Wikipedia, the free encyclopedia. This article is about androgens as medications. For androgens as natural hormones, see Androgen. Ergogenic use of anabolic steroids.

Use of performance-enhancing drugs in sport. Illegal trade in anabolic steroids. Pharmacy and Pharmacology portal. British Journal of Pharmacology. Houglum J, Harrelson GL, eds. Principles of Pharmacology for Athletic Trainers 2nd ed. Int J Sports Med. Mini Rev Med Chem. Anabolic-androgenic steroid therapy in the treatment of chronic diseases". Clinics in Endocrinology and Metabolism.

Pharmacology Application in Athletic Training. Clinical Guidelines for Prevention and Treatment. Royal College of Physicians.

Anabolic Steroids and the Athlete, 2d ed. Do testosterone injections increase libido for elderly hypogonadal patients? Retrieved November 17, Retrieved December 5, Freter 30 July Perry's The Chemotherapy Source Book. J Womens Health Larchmt. Results from four national surveys". Drug and Alcohol Dependence. Med Sci Sports Exerc. J Int Soc Sports Nutr.

Journal of Health Psychology. Medicine and science in sports and exercise. Principles and Practice of Endocrinology and Metabolism. In Katzung, Bertram G. Applied modifications in the steroidal structure". Medical consequences of doping with anabolic androgenic steroids: Handb Exp Pharmacol Eur Rev Med Pharmacol Sci. J Sci Med Sport. Annals of Internal Medicine. The Journal of Adolescent Health.

The Journal of emergency medicine. Clin J Sport Med. University of California — San Francisco. Journal of Sports Science and Medicine. Archived PDF from the original on 20 June A secret program of the German Democratic Republic government". Lay summary — ScienceDaily October 30, A Looming Public Health Concern? Annals of Clinical Psychiatry. What the psychiatrist needs to know". Advances in Psychiatric Treatment. Br J Sports Med. Archived from the original on And Other Performance-enhancing Drugs.

Am J Public Health. Archived from the original on 10 July J Acquir Immune Defic Syndr. Retrieved 2 January Proceedings of the Society for Experimental Biology and Medicine. The New England Journal of Medicine. Penn Clinical Manual of Urology. Protective Effects of Tea on Human Health.

Stacking can cause a massive gain in strength and mass, which a single anabolic steroid cannot deliver. But it is recommended only for advanced steroid users. While oral steroids are quick-acting and give faster results, they can be toxic if taken for a long time.

Therefore, some individuals will take oral steroids for a month and then switch to injectable steroids. Injectable steroids can take some time to show their effect, so people who are looking for quick gains may 'front load' or take a larger than normal quantity of the anabolic steroid initially. In palliative medicine, anabolic steroids are used for treating different diseases and debilitations.

But the dosage is usually small and there are no 'cycles', unlike when they are used to enhance physique. Your first concern if you are planning to use anabolic steroids to enhance your physique and performance should be safety. When used for therapeutic use, anabolic steroids are considered to be safe, but if you start abusing them, like some bodybuilders do, they can easily become dangerous.

Here is a list of things that you should keep in mind before you start taking anabolic steroids for muscle gain. Some teenagers are taken in by the photos of professional body builders in body building magazines and they start desiring bodies like that. They hear that anabolic steroids can help them attain such mass and they start experimenting with them. But they do not know how hard the body builder must have worked to develop his muscles. The teenagers also do not know that at their age, there is no steroid in the world that can get them bodies like that.

No individual should start taking anabolic steroids before he reaches the age of 25 and even then must resort to using steroids only if he has been lifting weights for at least 5 years.

Between the age of 12 and 26, the hormone level in a man's body will steadily rise. After 26, these levels start tapering off and by the time they reach 40, it is a fraction of its peak level. When puberty begins, there is a spurt in hormone levels, which causes male characteristics such as body hair, deep voice and increase in height to develop. In this stage of growth, the body is awash with naturally produced hormones and it is like a mild steroid cycle in itself. Introducing exogenous anabolic steroids into the body during this period will be counterproductive.

If an individual uses anabolic steroids without having reached his genetic potential, there can also be many side effects like stunted growth, stretch marks, hair loss, acne, water retention, gynecomastia and even organ failure. An anabolic steroid is not a replacement for a good diet and exercise.

While you may get some gains initially, without the proper nutrition and workout, you may have trouble hanging on to it after you finish your cycle.

Teenagers can achieve their natural limits by adjusting their food intake, eating foods that build muscles and following an effective training program. It is well known that the first steroid cycle should only contain Testosterone and no other steroid.

In fact, it can be repeated many times, with proper off-cycles and it will still give great results. All human beings and nearly all other animals produce Testosterone andfor this reason, it is the primary anabolic steroid. It is also considered to be the safest of all anabolic steroids, because the body already produces Testosterone and as a result, it is used to it.

When you inject yourself with Testosterone , it gives you an opportunity to gauge how your body will react to exogenous anabolic steroids, including advanced anabolic steroids. If you show a horrid reaction to Testosterone, you are likely to show an even worse reaction to other anabolic steroids which are basically derivatives of Testosterone.

Stacking multiple anabolic steroids in a cycle is a dangerous practice. If you have never used anabolic steroids before, you will not know what to expect. Another problem with stacking multiple anabolic steroids on the first cycle is that if the body ever shows an adverse reaction to the cocktail, there is no way to know what caused the reaction.

Note that, Testosterone must always be a part of all your cycles in the future too. Long steroid cycles can cause a host of problems. For this reason, a steroid cycle should not go beyond 4 weeks, with the preferred duration being 2 or 3 weeks. The most important reason why you should keep your steroid cycles short is because of the side effects that are associated with long cycles.

For one, there will be a drastic shift in your lipid profile. This can increase the risk of heart disease. As the steroid cycle progresses, the body's own production of hormones such as Follicle Stimulating Hormone, Luteinizing Hormone and Testosterone slow down and eventually shut down all together. But there will be a fairly high level of Estrogen from the aromatization of Testosterone and a normal level of Cortisone.

There is an enzyme called aromatase, whose main purpose is to catalyze the conversion of Testosterone into Estrogen. The male body needs Estrogen, which plays an important role in the maturation of sperms but too much of it can have negative effects.

It can lead to testicular atrophy, low libido, enlarged nipples, muscle mass loss and even potentially fatal health issues such as stroke, hormonal cancers and heart attack. Cortisone, an anti-stress hormone has a catabolic effect on muscle mass but it is usually suppressed by Testosterone. When adequate amounts of Testosterone are not present, Cortisone has a free hand and it starts liquidating the muscle mass that you may have developed through the use of a synthetic anabolic steroid.

The longer your steroid cycle, longer will be the time it will take for your body to renew its production of natural Testosterone. One of the side effects of long term steroid use is an atrophication of the Leydig cells of the testes. When the steroid cycle ceases, the Leydig cells are not able to restart the production of Testosterone immediately because at this point they are desensitized to the effect of the gonodotrophins. Eventually they will respond and the body will kick start its production of Testosterone but not before you have been through a lot of discomfort.

This is the reason why post-cycle therapy is an absolute must after the end of a cycle. Lower the dose of the anabolic steroids you take, lower your chance of developing side effects.

But you would not want the dose to be so low, that you are not seeing the results you want. This is where the minimum effective dose comes in.

A minimum effective dose can be defined as the lowest possible dose that will give you the desired effect. When they are on a cycle, most individuals intensify their training. Their frequency of training also increases compared to their off-cycle.

They are also more likely to follow a good diet. All these factors are also responsible for their gain in mass. Anabolic steroids certainly play a part, but exercise and proper diet are also important. Inexperienced anabolic steroid users will erroneously assume that the steroids are wholly responsible for their gains and so will increase their intake to get more results.

This is not the way to go about it. First make progress with a small dose, grow into it and then increase it by the barest minimum to improve results. You may have to take the minimum dose for a few cycles at least. Many first time users of anabolic steroids will straightaway start with mg per week dose, increase it to mg the second week, to mg the third and so on.

This is not necessary and it is very unhealthy. Note that the average production of Testosterone in the body of a normal male is about mg per week. A mg dose will be 10 times the normal value. Some professional body builders have become so insensitive to the effects of Testosterone that they are able to take more than mg of Testosterone every week when they are preparing for competitions , without showing major side effects.

Even mg per week is not a bad start for a first time anabolic steroid user. Unless you are a professional body builder or an athlete, there is really no reason for you to stack more than two anabolic steroids in a cycle. When the number of anabolic steroids you take increases, the stress on your organs also increases. The side effects will also become more severe.

If you have just started bodybuilding, do not take steroids. You should train at least for a few years before you can even think about taking steroids. Before starting a steroid cycle, undergo a full body checkup, including blood tests. This can tell you if you are in the best of health and whether you have any underlying conditions, that may be exacerbated by the use of steroids.

If you have such a condition that can be worsened by steroid use, make a conscious decision to stay away from them. Keep off strong anabolic steroids like Trenbolone and Anadrol until you have undergone several cycles with milder steroids. If you take them without guidance and without conditioning your body first, they can devastate your body.

These steroids are only recommended for professional body builders and even they are cautious about using such steroids. If you want to use anabolic steroids, as far as possible, use injectable ones. Oral anabolic steroids can exhibit hepatotoxicity if you take them in large and consistent doses. Oral anabolic steroids are alkylated at the methyl group attached to the 17th carbon.

Alkylation gives the anabolic steroid molecules more resistance to hepatic metabolism. But the downside is, the more a substance resists action by the liver, the more strain the liver undergoes. Through alkylation, a higher percentage of the anabolic steroid survives metabolism by the liver and is subsequently introduced into the bloodstream. This is the reason orally injested anabolic steroids show faster and better results.

The toxicity of an oral anabolic steroid depends on the anabolic steroid some are more toxic than others , how much you take of it dosage and for how long cycle length.

Most of the well known injectable anabolic steroids are not alkylated and are not so stressful on the liver. Consider using an aromatase inhibitor.

Aromatase inhibitors prevent androgens from being converted into Estrogen. Note that careless use of an aromatase inhibitor might lead to a drop in the level of HDL cholesterol the good cholesterol.

If you take anabolic steroids when you have a high level of body fat, you may see Estrogenic side effects like gynecomastia.

Adipose tissue is a store house of aromatase enzyme. When the Testosterone level in the blood increases beyond normal levels, the body starts converting the excess Testosterone into Estrogen with the help of the aromatase enzyme. If you are thinking of starting your first steroid cycle, you might have a lot of questions.

Steroid cycles can be complicated to a novice. The bigger problem is your lack of understanding of how the hormones work. There are many steroid cycles on the internet for beginners, but it cannot be said with certainty that what worked for someone else will work for you. Beginner steroid cycles can only give you a base to start from and as you progress, often through trial and error, you will find out more about what works and what should be avoided.

Most individuals on their first cycles are not able to reach their potential because they are not sure about what they want and how to go about it.

There have even been cases where people have started taking anabolic steroids randomly, with disastrous effects. Some people, when they do not see the effects they thought they would get, get frustrated and up their dose and lengthen their cycles. This can lead to bad results. Therefore, it is very important that beginners have adequate knowledge about steroids, their side effects, the results that can be expected and the mistakes to avoid. Note that using anabolic steroids to enhance the physique is illegal in the U.

You should also educate yourself about what kinds of anabolic steroids are available and how to use them properly, so that you can have a good experience. The truth is, there is no one-size-fits-all steroid cycle for beginners.

Factors like the individual's weight, age and height will make a difference. Every bodybuilder will need a custom cycle that is designed keeping his body features and individual goals in mind. You must first decide what you want to achieve from your steroid cycle.

Do you want to add bulk, so that you can enter a higher weight division? Are you looking to gain more lean mass or strength to play a sport? Do you want to reduce your body fat, so that you can add more definition to your body?

Note that you cannot cut fat and bulk up at the same time, so choose your priorities carefully. Next, you must choose the steroid that you want to use. Keep your first cycle as simple as you can. The first cycle should be a Testosterone-only cycle. Testosterone is naturally produced by the body, which means the chances that you will suffer from side effects is much lower than if you had started with an anabolic steroid like oxymetholone. At this point, you might be wondering which type of Testosterone you should use, since there are so many.

The compounds are the basically the same, the only difference being the number of carbons atoms on the ester chain. The more carbon atoms the ester chain has, the more the variant's solubility in oil. This solubility affects the compound's release into the bloodstream. Once you inject one of these esterified compounds into your body, it gets deposited in the muscle from where it will be released into the blood slowly. If you are a beginner you would want to start with an anabolic steroid that you would not have to take frequently, so in this case Testosterone Cypionate or Enanthate are perfect.

Some power lifters even use Testosterone suspension just before they perform because it works quickly, in as little as ten minutes. The main problem is that the existing steroid cycles for beginners have mostly been developed by individuals with no formal training in human biochemistry or physiology.

The internet has a lot of personal opinions and dangerous misinformation about first time steroid cycles. For instance, some sites have included Trenbolone in their first time cycles;but Trenbolone can be toxic and is not recommended for first time users. Some others recommend stacking, but stacking is only for experienced users. The first few anabolic steroid cycles are learning curves. Your first cycle, along with the subsequent cycles will help you gauge and explore how your body reacts to the hormones.

Here are a few preliminary considerations before you begin a steroid cycle. If you only take steroids and do not exercise and maintain a proper diet, prepare to get disappointed. One of the primary reasons why people use anabolic steroids is to gain muscle, but steroids cannot build muscles by themselves. You also need to train properly and eat well. Your training regimen should be a mixture of both strength training and muscle building exercises.

Undertake strength training exercises such as deadlifts, bench presses and squats. For muscle gain, do a minimum of eight sets of each exercise, with lighter weights. Also do tricep pushdowns, pec flyes, bicep curls and other concentrated exercises that will increase your muscle size. Another advantage of anabolic steroids is that they can decrease the time you need to rest between your reps.

Another effect of taking steroids is an increase in protein synthesis. They can bring about an increase in muscle mass and strength. That is why people who are suffering from debilitating diseases like chronic hepatitis and AIDS are administered steroids. But for the steroid to work, you should provide the raw material, which is protein. Meat, eggs, cheese, milk and yoghurt are rich sources of protein. You can also obtain proteins from pulses. Cholesterol-rich food such as egg yolk and dry fruits should also be eaten.

However, limit your intake of these foods because cholesterol has a tendency to cause deposits in blood vessels. Also consume lots of fiber. It will add bulk to your diet and prevent constipation. Potassium rich food such as dates, milk, apricot and peaches should also be eaten because steroids can cause a depletion in the level of potassium in the blood. If you want to start a steroid cycle and if it is your first time, start with Testosterone.

You may think, why Testosterone when there are so many other anabolic steroids on the market? Testosterone is a highly versatile anabolic steroid most anabolic steroids are Testosterone derivatives and it is well tolerated by the body. Under no circumstance should you start an oral anabolic-only steroid cycle. Many first time users of anabolic steroids, will often start with oral anabolic steroids.

It may be that the individual does not like needles or because oral anabolic steroids are easier to procure than injectable ones. The fact is, oral anabolic steroids are not made for solitary runs. But some people do use them to supplement their injectable anabolic steroid cycles.

Proper protocols should be followed when you are injecting yourself with anabolic steroids. If you are not serious about them, then anabolic steroids are not for you.

The dosage is very important and it will determine the benefits you receive. To see gains you will have to take a large dose a substantial improvement over a therapeutic dose.

Below the therapeutic dose, the body may suppress the endogenous Testosterone. A mg dose of Testosterone Cypionate or Enanthate in a week is considered a therapeutic dose. But if the dosage is increased to or mg per week, it will start supporting muscle growth. Advanced steroid cycles are only for those who have successfully completed several steroid cycles.

Advanced steroid users may use more potent compounds such as Trenbolone and Anadrol , but the Testosterone-only cycle is not ruled out either. A lot of advanced users would rather use Testosterone than any other advanced anabolic steroid. Many beginners are often surprised when they see that a senior is still using Testosterone which is thought of as a basic anabolic steroid, but they are misunderstanding the scenario.

These advanced users possess a complete understanding of their body and how it reacts to different anabolic steroids, which they have gained after years of using anabolic steroids. Apart from knowing how to procure legit anabolic steroids and possessing an extensive understanding of the administering protocol, advanced users also know what supplements they have to take to counteract side effects.

There are many kinds of advanced steroid cycles. Here is more information on some of them. The three-week Blitz is a week cycle and includes 5 anabolic steroids, each of which is taken for three weeks.

The user begins with Dianabol, which he takes for two weeks by itself. In the third week, he stacks it with Sustanon. The next week is a standalone Sustanon week. In the third Sustanon week, he stacks it with Anavar and so on. The Double Mini cycle is also a 14 week cycle. Here, the user stacks two anabolic steroids for six weeks, say Deca-Durabolin and Anadrol.

The next two weeks are recovery weeks, with HCG. In the seconds mini cycle which is again for six weeks , he stacks the same compounds again.

This eight week advanced cycle starts with a large dosage of three steroids- Deca-Durabolin, Testoviron Depot and Winstrol. The quantity is gradually tapered off, and by the end of the eighth week he is actually taking a very small dose of the three steroids. For this reason, the Inverted Pyramid cycle is quite popular among athletes who have to undergo drug testing. This steroid cycle should not be used by beginners for the obvious reason that it has very high initial doses. The 14 week Diamond cycle and the Inverted Diamond cycle are opposites of each other.

Here, the user begins with a small dosage of two steroids Dianabol and Sustanon which he increases until the eighth week. From the ninth week, he decreases the dosage, until it is back to the initial dosage. The 11th and the 12th week are recovery weeks, with HCG.

No matter how hard a natural body builder works, he will never be able to obtain the mass and strength that a body builder taking anabolic steroids can achieve. But even the latter has to follow a dedicated exercise routine to build up his muscle mass. There is another reason why you have to workout. Sometimes, steroids can lead to excessive bloating and cause other side effects. The best way to fight these problems is to burn body fat and treat the water retention.

To shake your muscles out of homeostasis and get them into body building mode, you will need to work out intensely. Keep increasing the weights as you gain strength, so that stress is maintained on the muscles. If you are able to perform sets easily and you are not facing muscle failure, the weights are not enough and you need to add more weight.

Stressful exercises provide stimulation to the muscles, but they grow only when they are at rest. Structure your workouts in such a way that you are able to exercise all groups of muscles at least once a week. A sudden increase in mass can put stress on the heart. It is a solution that allows you to speed up the muscles and, above all, reduce the time needed for recovery after exercise.

Bear in mind, however, it is critical that hormonal steroids and, if taken without skill, hard work can disrupt the body.

To prevent this, you need to use these funds wisely and in a thoughtful manner. How to perform a safe cycle? Here are some tips on this issue. The first cycle If you reach for steroids for the first time in my life, remember that you can not immediately decide on the advanced funds.

At first select the value of that present themselves good results, while giving little side effects. Dianabol - especially good for those who want to avoid injecting drugs, it is relatively cheap and safe - is used by most of those who begin their adventure with steroids - but remember you need a good cover for the liver, enantal - similar to testosterone propionate, is of injection, it is administered every 5 days.

Testosterone propionate - safer than Dianabol, because in small doses does not adversely affect the liver, injection - fed up to 2 days - so it is easy to break the cycle in case of complications. These measures work as smoothly, but also bring visible effects - weight gain after a cycle of approx. It is, of course, abide by all of the precautions that we will describe later in this article, because they also apply to each cycle taking steroids.

Precautions - what it is good? There's no denying that the adoption of measures such as steroids is a big burden on the body. Especially at risk is the liver. Therefore, it is essential to take preparations Curtain - especially when taking oral agents. They work best pharmaceuticals such as Essentiale Forte. Ensure you should also: As we can see, a safe steroid cycle is one that is run with reason, with proper supplementation and the cover of the liver and in accordance with recommendations.

If you are thinking about their actions and will lead a series of consciously, then chances are that there will be health complications are small. Buy steroids uk with us and Be sure You have legit anabolic! Remember that if you decide to take steroids - you're doing it on your own. They are in fact drugs that can seriously harm your body in many ways. Buy steroids to United Kingdom online in trusted shop - steroids-uk. This team can also include intermediate bodybuilders.

Check that steroids are most popular and why. Ranking the most popular steroids Steroids differ sometimes actively, properties, active substances which they contain, side effects, and use.

Iamges: anabolic steroids low dose

anabolic steroids low dose

Rittmaster et al, ; Kumar et al, a; Hayes et al, There is a saying among anabolic steroid users, 'If you do not want to inject, anabolic steroids are not for you.

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This is not necessary and it is very unhealthy.

anabolic steroids low dose

Are You afraid to…. This will allow you to ddose them at the same time. Trenbolone Enanthate- mg every week. Some of these counterfeit anabolic steroids may not have the anabolic steroids low dose that the buyer wanted. The first cycle sterods anabolic steroids low dose a Testosterone-only cycle. Some examples of virilizing effects are growth of the clitoris in females and the penis in male children the adult penis size does not change due to steroids [ medical citation needed ]increased vocal cord size, increased libidosuppression of natural sex hormonesand impaired production of sperm.